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KMID : 0613820080180101435
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Journal of Life Science
2008 Volume.18 No. 10 p.1435 ~ p.1441
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Anticancer Activity of Ethanol Extract from Peel of Citrus junos and Poncirus trifoliata on MCF-7 Breast Cancer Cells
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Kim Ji-Eun
Park Joon-Hee
Kang Byoung-Won
Seo Min-Jeong
Choi Yung-Hyun
Lim Hak-Seob
Seo Kwon-Il
Kim Jung-In
Joo Woo-Hong
Lee Bok-Kyu
Jeong Yong-Kee
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Abstract
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In this study, anti-cancer activities of peel of Citrus junos (CJP) and Poncirus trifoliata (PTP) on MCF-7 breast cancer cells, and anti-proliferative effects of cancer cells induced by environmental hormones were investigated. The ethanol extracts of CJP and PTP inhibited cancer cell growth and induced apoptosis at the concentration over 300 ㎎/㎖ treatment for 72 hr. Morphological change of MCF-7 breast cancer cells were observed treated with the CJP and PTP of 500 ㎎/㎖ concentration for 72 hr, and apoptosis was induced by activation of caspase-3. The proliferation of MCF-7 breast cancer cells was decreased in a dose-dependent manner treated with various concentration of CJP and PTP, when compared with the control at 300 ㎎/㎖, the proliferation of the MCF-7 breast cancer cells of both extracts was decreased over 70% and 80%, respectively.
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KEYWORD
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Poncirus trifoliata, Citrus junos, MCF-7 breast cancer cell, anti-cancer activity, antiproliferative effect
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